Physicians' and Patients' Perceptions and Practices Concerning Antithyroid Drug-Induced Agranulocytosis

Abstract Objectives We aimed to ascertain physicians' attitudes and practices evaluate patients' knowledge of antithyroid drugs (ATDs). Also, we would like review the quality information on Internet (in Arabic) concerning ATDs' including agranulocytosis. Methods A mixed methods study design was employed, an online physician questionnaire, structured interviews patients ATDs, evaluation web sites containing in Arabic. Results Most physicians (82.6%) thought frequency agranulocytosis receiving medications is 1 5 per 1,000 annum. Nearly 72% participants reported educating their about risk when they receive ATDs regularly verbally only. should be warned sore throat fever. More measure a white blood cell (WBC) count only if patient developed suggestive symptoms (57.0%) than those who do it routinely (43.0%). If develops suspicious symptoms, that most efficient way deal with this attend nearest hospital emergency department (37.2%). Less can go any facility laboratory WBC (29.8%) or contact usual endocrine clinic (24.4%). half (49%) were aware side effects but 17 respondents (17.3%) identified one both two typical The received evaluated as “not good at all” “poor” by 19.2%. Over two-thirds (69.7%) amount right. (72.5%) preferred during consultations physicians. Since starting 37.0% have experienced different various combinations. However, one-third (12/37) had urgent count. 190 selected Arabic revealed significant variation advice. Six percent 11/190 (5.8%) considered good. Conclusions findings suboptimal inconsistent perceptions put ATD Middle East increased call for more action from professional advocacy groups.